Mathematical Models of the Impact of IL2 Modulation Therapies on T Cell Dynamics

Several reports in the literature have drawn a complex picture of the effect of treatments aiming to modulate IL2 activity in vivo. They seem to promote either immunity or tolerance, probably depending on the specific context, dose, and timing of their application. Such complexity might derive from the pleiotropic role of IL2 in T cell dynamics. To theoretically address the latter possibility, our group has developed several mathematical models for Helper, Regulatory, and Memory T cell population dynamics, which account for most well-known facts concerning their relationship with IL2. We have simulated the effect of several types of therapies, including the injection of: IL2; antibodies anti-IL2; IL2/anti-IL2 immune-complexes; and mutant variants of IL2. We studied the qualitative and quantitative conditions of dose and timing for these treatments which allow them to potentiate either immunity or tolerance. Our results provide reasonable explanations for the existent pre-clinical and clinical data, predict some novel treatments, and further provide interesting practical guidelines to optimize the future application of these types of treatments

Tareas docentes intradisciplinarias para la asignatura Células, Tejidos y Sistema Tegumentario en la Escuela Latinoamericana de Medicina

Introducción: La orientación, realización y evaluación de la tarea docente integradora ocupa un lugar importante dentro del proceso de enseñanza- aprendizaje en la Educación Médica Superior. En el contexto de un aprendizaje intradisciplinario los estudiantes adquieren mayor nivel de integración y generalización entre los conocimientos adquiridos en las diferentes asignaturas de una misma disciplina. Objetivo: Determinar los fundamentos teóricos- metodológicos para la elaboración de tareas docentes intradisciplinarias de la asignatura Célula, Tejidos y Sistema Tegumentario y Biología Molecular en el proceso de enseñanza aprendizaje de la carrera de medicina en nuestra facultad.Facultad de Odontologí

Antigenicity and Immunogenicity of a Synthetic Oligosaccharide-Protein Conjugate Vaccine against Haemophilus influenzae Type b

Polysaccharide-protein conjugates as vaccines have proven to be very effective in preventing Haemophilus influenzae type b infections in industrialized countries. However, cost-effective technologies need to be developed for increasing the availability of anti-H. influenzae type b vaccines in countries from the developing world. Consequently, vaccine production with partially synthetic antigens is a desirable goal for many reasons. They may be rigidly controlled for purity and effectiveness while at the same time being cheap enough that they may be made universally available. We describe here the antigenicity and immunogenicity of several H. influenzae type b synthetic oligosaccharide-protein conjugates in laboratory animals. The serum of H. influenzae type b-immunized animals recognized our synthetic H. influenzae type b antigens to the same extent as the native bacterial capsular polysaccharide. Compared to the anti-H. influenzae type b vaccine employed, these synthetic versions induced similar antibody response patterns in terms of titer, specificity, and functional capacity. The further development of synthetic vaccines will meet urgent needs in the less prosperous parts of the world and remains our major goal

REPORTE CORTO/SHORT REPORT - CLONING, EXPRESSION AND CHARACTERIZATION OF THE P64k OUTER MEMBRANE PROTEIN FROM N. meningitidis

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